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KMID : 1059520130570020241
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Journal of the Korean Chemical Society
2013 Volume.57 No. 2 p.241 ~ p.245
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Design, Synthesis and Antibacterial Activity Studies of Novel Quinoline Carboxamide Derivatives
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Shivaraj Yellappa
Naveen Malenahalli H.
Vijayakumar Giriyapura R.
Kumar Doyijode B. Aruna
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Abstract
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A series of novel quinoline-6-carboxamides and 2-chloroquinoline-4-carboxamides were synthesized by the reaction of their analogous carboxylic acids with various amine derivatives in the presence of base TEA and protecting agent BOP at room temperature. Synthesized compounds were confirmed by spectral characterization viz IR, 1H-NMR, and MS. Antibacterial activity carried out against Escherichia coli and Staphyllococcus aureus indicated that the synthesized compounds were active against these microorganisms.
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KEYWORD
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Quinoline-6-carboxamides, 2-Chloro quinoline-4-carboxamides, Antibacterial activity
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